The Imperfectionists by Tom Rachman
My rating: 3 of 5 stars
A literary look at evolution
I have this idea that I need to get out of my head. I need to preface it by making the following disclaimers. I am an atheist. I have no interest in ‘proving’ any of the faithful that he is wrong. I am not asking anyone to reconsider his position, theological or philosophical. I simply wish to tell a story and ask a question, which admittedly is really an observation.
Here goes.
I think every religion seeks to place man within the cosmos, and this position embodies a contradiction. Generally, religions claim mankind is insignificant, needing the grace of a deity to make their lives meaningful. The contradiction is that a deity deign spend time on helping the ants find salvation.
In this context, and specifically in the Judeo-Christian tradition, I made up the following. From my reading of the Bible, God sounds like a son of a bitch. Granted, I was more interested in the Old Testament, but there are enough militant statements in both Old and New Testaments speaking to man’s insignificance and need for God’s grace. God provides meaning to life. Fulfilling His desire gives purpose to man.
So, the story I concocted is that evolution need not be nemesis of religion. In fact, it would fit in magnificently (in a literary sense. It is based on my interpretation of the character of the Almighty). One image I hear from Christians is that we are akin to children playing in the mud. Kids playing in the mud certainly can’t clean each other well. You need someone not in the muck. The analogous situation is that any creature less than God to grant purpose and meaning is a profane idea. If God does not exist, the false idol/prophet/holy man dispensing advice and using philosophy to give us purpose is like having one dirty child cleaning another. We need an omniscient being to become a cosmic referee, as it were.
In this context, evolution – in which the central principles are supported by a wealth of evidence from molecular biology research, fossil records, genome comparisons, the selection of antibody resistant microbes, dog breeders, and orchid growers, for example – simply underscores how insignificant we would be without God.
For example, we know that there is a record of life going back at least 500 million years. Humans share a genetic code that have similarities to apes, monkeys, dogs, mice, cats, lizards, birds, and fish. There is also a library of ape fossils where one can see semblance to human bone structures. After showing us that mankind is a part of the world around him, wouldn’t it make sense to show mankind that by possessing God’s grace (whether it be salvation, purpose, or insight), this trait allows man to transcend his status as animal? Doesn’t such a story imbue mankind with distinction conferred entirely by God, that without him we are in fact a bunch of great apes?
My observation/question to the religion-inclined is, “Can you show me where in the Bible you can refute this story?”
Since I did base this (OK, maybe I am guilty of trying to needle Christians) on a literary reading of the Bible, can you really argue whether my interpretation is so off base? What would you use as evidence, some passages from the Bible that I would be unlikely to use? How would you decide among all the existing creation myths? What are your criteria for dismissing Zeus and the Olympians but not Jesus, or Allah, or Yahweh, or the Buddha?
Book recommendation – Walter Kempowski’s Did You Ever See Hitler?
A book recommendation from Lev Raphael over at The Huffington Post. What is funny is that when I tried getting more information on him – Das Echolot: Barbarossa ’41: Ein kollektives Tagebuch looks interesting (Sonar: Barbaross ’41: A collective diary) – I also came across Es Liegt Mir Auf Der Zunge: Geschichten mit Geschmack (It Lies on My Tongue: Stories with Taste.)*
* Sorry if I didn’t do it justice; my translation. I am reasonably sure that I got the gist of the title, although I can’t be sure if it’s a book of food criticism/culture/history or if it’s a book of stories. Die Geschichte can mean either history or story. I took German in college and took a year to study biochemistry at the then-called Technische Hochschule Darmstadt. Alas, I learned German the hard way, just by talking when I can. As I hear it, having a girlfriend whose first language is what you are interested in learning helps immensely.
Yes, we did read Guenter Grass (and Kafka, and Mann) in the German literature course I took. Even more so than my graduate thesis advisor, I looked upon my German professor as a mentor. I think he was relatively impressed with how quickly I took to the language. Sadly, this was at an engineering school; the non-engineering majors they offered were biochemistry and biotechnology. Just joking, but nearly true (mathematics and physics were also offered.) This is more information that suggests I should have gone into Literature or History.
Looking up more information about these books, I came upon a surprisingly amount of German erotica (Dann zerteilt meine Zunge deine wunderbare Pflaume und ich lecke dich tief und drängend.) Regardless, I can go to Schoenhof’s Foreign Books – but alas, the online catalog shows that they stock only Kempowski’s biography .
Relativity at human scales
The nice people at Ars Technica wrote about a Science paper published today. Through the use of precise optical clocks, researchers were able to show the effects of relativity for objects in motion and at different distances from a massive object (i.e. Earth). Traditionally, effects become “obvious” and large when objects move at near light-speed. It is interesting then to see that macroscopic objects (like huge clocks and by extension, things and people) can also experience relativity, albeit with inconsequential effects. Researchers were able to show that moving a clock at 22 mph or placing a clock about 1 ft higher off the ground will result in that clock ticking slower. Both are good reads.
Linda Buck, an olfaction researcher, retracts more papers
Something close to home. The Scientist and New York Times reports that Nobel Laureate Linda Buck retracted two papers recently. This follows a retraction of a Nature paper from 2001. All three papers featured work done by a post-doc, Zhihua Zou. The retracted papers have no bearing on the work Buck and Richard Axel had performed in identifying the family of G-protein coupled receptors, which won them the Prize.
Rather than focusing on the work in the retracted papers, I would like to explain why, fortunately enough, the retractions do not substantially alter our view of how olfaction works.
First and foremost, independent researchers, using independent means, have found similar results presented in the retracted papers. The main points from the three retracted papers are,
1) Using a genetically encoded neuronal tracer, the paper purported to show that neurons that express the same olfactory receptor connect to neurons that wire to the same brain regions responsible for olfactory processing (Zou et al, 2001).
2) That a marker of neuronal activity, c-fos expression, showed that activity patterns in olfactory cortex is reproducible across animals and are typical for a given smell, a molecule of which is termed “odorant” (Zou et al., 2005).
3) That mixtures of smells activate neurons that respond to the components individually (the pattern of activation is a summation the patterns evoked by single odor components.) (Zou and Buck, 2006).
The peripheral olfactory system can be described as follows. The primary, sensory neurons are situated in the nasal cavity and are responsible for detecting odor molecules. These neurons form connections with neurons of the olfactory bulb. In turn, OB neurons project to “higher olfactory centers”, which includes the piriform cortex.
For the first retracted point, there already exists research showing that connections into the piriform cortex from the olfactory bulb is both convergent and divergent. This can be shown by labeling small groups of neurons in the olfactory bulb, and then watching where the labels wind up. In the piriform cortex, one can see the label over large areas even if the label started out in a confined area in the olfactory bulb, thus showing divergence. A small location in the piriform cortex also receives neurons from all over the bulb (i.e. convergence) when using labels that travel from the cortex to the bulb.
The specific detail offered by the Buck group is that the neurons connecting to piriform cortex share a common origin. That is, the sensory neurons in the nose connect to olfactory bulb neurons that in turn connect in to clusters of physically near neurons within the piriform cortex. The groupings at this level suggest that the piriform cortex could be built from many such groups of neurons. Thus, when an odor molecule activates receptor neurons in the nose, eventually, clusters of activity could be found in the piriform cortex. These spatial patterns may result from the sums of all the receptor neurons that were activated (both these points were covered in Zou et al., 2005 and Zou and Buck, 2006). The spatial organization may reflect an (still unclear) advantage or need for neural processing.
That is a very rough sketch of some basic ideas in mammalian olfaction. As noted, tracing experiments, performed in separate labs with different methods show that there is some structure in where neurons form projections. Whether one can make specific statements linking a response and/or connection to some neurons in the nose is at issue.
One should note that the retractions from Buck lab do not indicate misconduct (yet) – i.e. doctoring and faking of data. The problems could have arisen in analysis. Indeed, Illig and Haberly, in 2003, using the same c-fos methodology to indicate activity, found that the piriform cortex had widespread activation in response to odorant exposure. A “pattern” of activity was absent. Using both electrophysical recordings and optical indicators of neural activity, similarly wide-spread activity was also observed in mice and rats. Even in zebrafish, wide-spread activity within the olfactory cortex analogue was observed. The clustering seen by the Buck group could have arisen by chance clustering of the c-fos signal and could have been enhanced by the analytical techniques they used. I do not know how the data was analyzed to lead to the results published in the paper, but there are mistakes one can commit, without any malfeasance intended.
A note on the methods: there are some significant differences in the way activity is reported with c-fos when compared to electrophysiological and optical recordings. Expression of c-fos is linked to calcium influx in activated neurons. The usual method in evoking this response, to create enough signal against a background, is to expose the animal for 30-60 minutes, to a single odorant. In contrast, the other techniques show responses lasting less then a second (and at millisecond precision) in response to exposure to smells. Further, the chain of events leading from activated neuron to c-fos expression is unknown. For example, how many electrical impulses (i.e. action potentials) in neurons correspond to a given level of c-fos expression? While useful as a gross measure to identify areas of interest, the c-fos technique ultimately lacks some of the advantages researchers need to make definitive statements about smell processing at the actual time scales relevant to brain function.
That is an important distinction: techniques that are similar to those Linda Buck’s lab used have worked in other labs. The key point is that we can no longer use the tracing results that purported to show connections at 3 structures in the olfactory system. Although we no longer know the specific identities of the connected neurons, the general principle of convergent/divergent connections remain. As for her other conclusions in subsequent papers, there is enough evidence to suggest that the organization of activity in the piriform cortex occurs in the timing of neural responses and not necessarily by their physical locations. Further, the technique her group used to assess activity has disadvantages in assessing neural activity at millisecond time scales (which is the regime where neurons work. Thus the findings themselves, although retracted, do not alter at a deep level what researchers think about olfaction.
How to do well during one’s post-doctoral training
The Scientist has published some advice for training post-docs. More emphasis needs to be placed on what a career in science entails. Often, the key motivation in doing science is that experiments are fun. However, that isn’t doing science.
Being a scientist means: looking for gaps in existing literature, stringing together theses gaps to build a research program (i.e. grant proposal), write grant proposals, manage money, manage time, learn to interact with colleagues, build working relationships (or at least acquaint and introduce oneself) with researchers outside lab, expose oneself to science (be selective!), do the bench work, and analyze data.
If you are a graduate student, then your job is to turn data into figures. Doing so will train you to think about how best to communicate a finding. I would argue that, even if you have an “n of 1”, you should start making the graphs, tables, curves, and so on. Have the framework in place to receive data.
This is the corollary to displaying your hypothesis in a prominent location and thinking if it needs to reworking.
Essentially, focus on telling people what you are doing, why, and what you have found so far.
In doing this, you will naturally look into literature to fill in gaps in your knowledge and also to find novel experiments to try.
This set of observations is not meant to be authoritative. It is simply something (new) for you to try if you haven’t already done so. If you want to add to this list, let me know. I can link back or just update this post.
BR Myers reviews Jonathan Franzen
BR Myers, of The Atlantic, has written a scathing review of Freedom. I also recommend Myers A Reader’s Manifesto. He thinks Franzen writes about people of no consequence in pedestrian language. Eleanor Barkhorn, also of The Atlantic, collects a set of rebuttals.
Franzen and Picoult, yet again
Back when Oprah Winfrey selected Jonathan Franzen’s The Corrections, I saw a distinct lack of graciousness from various authors and book critics. As I remembered it, the reaction was almost a dismay and outrage that she would drag a piece of literary fiction through the mud that constitutes the low-brow mainstream. There also seemed to be an undercurrent of snobbery as applied to Winfrey. She had chosen mainstream potboilers and melodramas; selecting Franzen had the appearance of Winfrey ‘trying’ to seem smart or high-brow.
As if a woman who built a billion dollar media company from nothing lacks the intelligence or emotional acumen to understand literary fiction. As if she needed to justify why she veered from choosing another mass-market novel about a broken romance or an issue. As if her business sense couldn’t translate into her appreciating Literature. As if she needed the pretension of reading Literature to convince anyone that she has a rich, considered inner life.
Franzen, I am sure, will take his new opportunity to address why the flap over the corrections. He had even made some statement about it already, blaming his lack of experience in dealing with the exposure. Sure. Whatever. I do give him some credit; I distinctly remember a lot of other people slapping down Oprah, but nothing so bad coming from him.
I continue to detect this vein of elitism coming various poison pens, today. This time, at least the arguments are carried by authors.
I will be clear here; I have not ever read a work of so called Literary fiction that was difficult in an intellectual sense. No words stump me; no metaphor goes unnoticed or misunderstood; no linguistic fireworks ever go unappreciated. I appreciate the talent, skill, and craft going into beautifully constructed novels. I understand the themes and issues that are the reasons for an author to write. I love complex characters who straddle the gray of living in the world. I like denouement and dramatic closure, which I do not confuse with a tidy, happy ending where all problems are resolved (see Peter F. Hamilton’s The Evolutionary Void for this. This is a three volume space opera and contains a novel within a novel. There’s a lot going on. The series boils down to a happy ending, for everybody, in the last 2 or 3 pages. This struck a wrong note with me. But it’s still a fantastic read.) I also understand that writing fiction is not my forte.
A novel is never the intellectually difficult exercise that science is, for the reader. Literature isn’t rocket science. It isn’t even a social science. This is not a criticism so much as an observation. The novel embraces life in its messy, tangled glory. The scientist strives to tease out the role specific parts play in creating that mess.
Both are difficult, but in different ways. Literature is difficult as an act of creation; science is difficult in its comprehension. In Literature, all asides, digressions, and verbosity, when done well, contribute to the greatness of the work. In a way, writers make the text hard, but in an aesthetically pleasing way. In science, the descriptions and discussion are stripped bare, because the ideas, assumptions, and experiments are already convoluted. Each assumption is based upon a foundation of many other ideas, all linked to the strength of experiments addressing them. In many cases, the experiment at hand is to address some inadequacy and nuance in a previous paper that may open up new lines of inquiry. To make things any harder to understand is to waste a scientist’s time. Either way, badly written novels and scientific papers will accomplish the same thing: thrown at a wall in disgust and then ignored.
And the phrase ‘novel of ideas’ annoys me. Apparently these Literary authors – and the critics who set themselves up as professional connessiuer of Literature – have done a great job creating a sandbox from which genres are excluded. So we get stilted prose and writing about white, male assholes who behave badly, observe the shit leading to his situation, and then internalize all such snarky observations to himself while never making a mental connection with his (usually sexy) significant other. And so the true novel of ideas, found in science fiction, is ignored.
I am sure that I just conjured visions of space ships, phasers, droids, and Death Stars. The sci-fi I refer to is that branch known as hard science novels – for example Stephen Baxter. This type of novel are fantastic extrapolations of current state of the art science. Admittedly, one-dimensional sci-fi read like either a Star Trek episode or a technical manual, but the best sci-fi actually examines the human condition in the context of new technological and social environment. It is an extension of the basic premise of what white, male literary authors write about. Instead of some recognizable human event, some sci-fi authors are interested in placing recognizable, human characters in unfamiliar confines (I think P.D. James’s The Children of Men is a good example of this). And yes, a Baxter novel, a William Gibson novel, a Charlie Stross novel, a Margaret Atwood novel and especially a Neil Stephenson novel provide more raw ideas than most literary novels hope to capture.
Even during my essay on Medium Raw, I was really thinking of this divide between what the so-called professional critics and “serious” chefs and what appeals to the public. I do find Literary critics and authors (and ultra serious chefs and food-writers) to be pretentious, as if what they do is so hard to understand (I recognize that it is hard to write a novel and to create new dishes. But to understand a novel or to enjoy food? No.) Theirs is elitism without merit. While talented, the degree to which their talent engenders appeal depends on the fancies of the buying public. This is true because everybody is selling to the public now, not a few pricey artisanal items to the extremely wealthy. The fact that some authors (or pop stars, or movies) get all the sales (or ratings) do not mean that non-blockbuster authors do no good. Of course they do. Unfortunately, most people focus on the big winners (like a Stephen King, or a James Patterson), but there ought to be enough good writers occupying the midlist and who are deserving of some critical analysis or exposure.
I think this is a point that Jennifer Weiner and Jodi Picoult were trying to make, in the Huffington Post interview . It seems ludicrous to assume that if an author makes money, he can’t possibly be good. By the same token, just because a writer continues to starve does not give him any status; sure, he loves writing and sacrifices for his art. But perhaps he continues to suffer because he is not all that good. As Koa Lani pointed out in her rebuttal, even if every author profiled fit the “white, male, from Brooklyn stereotype” that Weiner and Picoult satirized, it may be that profiled and acclaimed authors deserve the adulation. I do not see the two points as contradictory: 1) that mainstream literature probably won’t field as many impact novels and writers but they are there and 2) that generally, writers who get profiles deserve it, even if others who deserve the press do not get it.
What I find strange is that everyone accepts that there are so few good writers worthy of a professional connoisseur. Here’s the problem: I’m never sure whether the critics like a book sincerely or if it is a pose. When I was reading Bourdain’s Medium Raw, he made similar points about food critics. It seems strange to him that critics have a death watch culture, where, once a chef is proclaimed to be the best cook ever, everyone is now scrutinizing his every move, pouncing on the point when he began his slide. It really is just snobbery, rather than any sincere appreciation of the food, that drives these people. Just as these food critics wish to glow in the luster of their “discovery”, so too must they exact a tax on the fall from the summit of said chef. There are such enthusiasts and critics in every modality (movies, TV – from which the phrase “jump the shark” was derived, music – please see Nick Hornby’s Juliet, Naked, and books), and because they do not create, they nominate themselves as arbiters over those who do. As if an opinion of a book is somehow as important as the book itself or even a discussion of ideas contained within (the first point is discussed in Mark Helprin’s Digital Barbarism.) These poseurs wish to be the first to trumpet talent and the first to sound the end.
It wouldn’t astound me if critics are affected by what their peers think (no one wants to miss a Franzen or Lethem, and no one wants to coronate Nicholas Sparks, I presume.) Just as likely, perhaps critics just simply want to be contrarian (see the Roger Ebert vs. Armond White).
This isn’t necessary a bad thing, but it could help explain why the stereotype “white, male, from Brooklyn, and who teaches creative writing” is so well represented in Literary reviews. In Leonard Mlodinow’s The Drunkard’s Walk, he writes about the randomness of super-success. Not that the idea of good and bad is a crap shoot, but the fact that we can’t really predict why some books and movies do blockbuster business while others designed for that purpose go ignored. It is telling that one piece of research Mlodinow presented has to do with music and how it is ranked. Two cohorts of subjects were asked to rank songs. The difference between cohorts is that one cohort has no knowledge of how others ranked the songs, while the second did. The first cohort ranked songs as in distributed manner: the “likes” were spread over many songs. The second cohort had a “sharper” profile, where a few songs garnered high-rankings. Thus judging books by criticism or by sales might be a reflection of the herd mentality.
It is no secret that our opinions and evaluations can also hang on inconsequential details. The canonical stories come from orchestra auditions, where female performers are usually relegated to second-chair status – unless the auditions occurred with the performer behind a screen. Even among performers of relatively equal looks and talent (for whatever it’s worth, the researchers aimed to build the most homogeneous of sample sizes), the manner of dress and visual style could influence what evaluators think. If one listened to these performers without visual cues, he would be hard pressed to tell the difference (that was also an experiment in the study). It seems strange that we are all so concerned with “the best”, when even the most informed opinion remain just that, an opinion. I am not sure if it is meaningful to make the distinction between the levels of good a writer achieves, because this evaluation depends so much on how the critic is feeling at that particular moment.
One final example; in other posts in this blog, I have tried highlighting the research of Dave Berri, who has done a bit of work documenting how even recognized experts in a field may not be using the right metric or standard for evaluating talent or productivity. In sports, we have all the pertinent information to judge such matters. However, it is difficult to make the same assessment for the worth of books, of music, of movies, of food, of wine, and so on. There are technical aspects to discuss, sure, but after some level of proficiency, it becomes a matter of opinion whether one book is better than another.
To the sincere critics who wish to look for something new, I would add the following thoughts. Because I feel strongly that my verdict on a book (good or bad) is irrelevant, I take pains to write simply about my engagement with the story, themes, ideas, and characters in a book. I pitch what I write here as taking part in a discussion; I prefer to call these essays about books rather than analysis or criticism. I try not to place the books in the authors’ context but in my context (within constraints.) I understand fully that what I say here is not authoritative and is merely an opinion. The most I hope for that you find my opinions thoughtful and an interesting point of view.
Predicting the Nobel short-list
And interesting article in The Scientist about how David Pendlebury, a citation analyst at Thomson Reuters, built a simple model to identify researchers who are candidates for winning a Nobel Prize. He used a simple citation and recognition model (the more someone is cited and the more prizes they have won, the more impact these researchers are thought to have.) The article is short and fun, and although the reporter Bob Grant notes the correct predictions, it would have been nice to see how often the model missed.
Less Than Zero
Less Than Zero by Bret Easton Ellis
My rating: 2 of 5 stars
I can see that this book is the spiritual ancestor of Lev Grossman’s The Magicians. Minus the man-whore scene. It differs from The Magicians in the way the character’s apathy is shown. Ellis literally shows us the things Clay does. He travels around LA in a stupor, home on Christmas break from college. He sees things and experiences. But the neat thing is that I still sensed his desperation, his need for contact and to feel, to break away from the decadence of his teenage life. Grossman took the opposite approach; the reader knows what Quentin feels. Regardless, both writers made successful portrayals of walking pieces of shit.
One other note: I have the same thought on reading this as I did Margaret Atwood’s The Handmaid’s Tale. Both writers used simple syntax and grammatical construction. So much so that the book just drones.
<satire>It is a lot of monotony without any break and without any spark to life and life is boring and then my friends show up in their new Mercedes and where is my coke dealer but I would rather go out with my girlfriend but instead we go home and sit on her bed smoking pot. </satire>
At the time, I had thought Atwood’s point was to make her character seem limited in terms of her intellect, enforced by the patriarchal society. But then I saw that it was actually Atwood’s writing style. I have not yet read Ellis’s other books (American Psycho and Imperial Bedrooms are next), so I will find out if this drone actually served to underscore Clay’s being inured to life or if that’s Ellis’s writing style.